There is a lot to consider, lot of good advice here already, Mike in WA made a good point about trades like HVAC, Plumbing, Electrical and Drwywall.
Another good point about future considerations, one level, accessible baths etc., you don't necessarily have to adhere to those details, but the point is right on the money, always consider future uses in your design, or it will cost you triple later.
I spent much of my career as a construction manager, general contracting and specialty contracting, multi million dollar size jobs, but the philosophy of sound management practice can and is very applicable to smaller scale residential projects.
You must have a complete set of drawings and specifications, be prepared to separate precise scopes of work for each subcontractor, use a subcontractor agreement (contract)always and utilize a percentage of completion payment schedule, also you need to outline a project schedule and identify a critical path within it, if you want to meet your schedule, your subs must buy into the schedule, make it part of the contract. Keep yourself organized and focused at all times, no if's and's or but's, things can get out of control, or less than desirable situations can arise, I've seen plenty of it in my career, those subcontractors need to provide good workmanship, be able to coordinate their work, ( you must make sure the trades are coordinated ) and be held accountable for the schedule and down to the small details towards the end, that will be on the punchlist.
If you can do things like sitework, you can save some money there, concrete and formwork is best left to a sub, make sure to coordinate all penetrations, stub ups and any attachments to the concrete, walls and slabs. Your design documents must be prepared by a reputable designer, also coordinated, structurally and architecturally, including all mechanical, electrical and plumbing trades ( M.E.P ) as well. The remainder of the work that you can do will save you money, but will take up a lot of your time, so you have to weigh it out.
I could go on and on, lot of things to consider and many different ways things can be done, but don't ever be foolish with money with any outside subs or help, that is the ONLY leverage you have, so many people get taken by fronting money, DON'T do it. Providing materials is ok, you don't pay a contractors mark up, but for M.E.P. trades it can be difficult to purchase from contractor only supply houses, though if you can set up an account with any places like that, those trades are expensive bought out, so if you can get those materials and have a M.E.P. person install, pay em a good labor rate and you'll come out ahead. Again, lot of things to consider, stay focused and organized, common sense goes a long way when acting as your own G.C. !